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M94A3207.TXT
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1994-10-25
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Document 3207
DOCN M94A3207
TI Further studies on the ability of lithium (Li) to minimize the blood
cell toxicity of AZT.
DT 9412
AU Gallicchio VS; Kazini S; Townsley E; Hughes NK; Tse KF; Scott KF; Lin J;
Birch NJ; Division of Hematology/Oncology, University of Kentucky,;
Lexington 40536.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):129 (abstract no. PA0137). Unique
Identifier : AIDSLINE ICA10/94369368
AB OBJECTIVE: To further investigate the capacity of Li to influence the
hematopoietic toxicity of AZT. METHODS: Normal mice (C57BL/6) received
dose-escalation AZT (0.1 and 2.5 mg/ml, i.p.) respectively for
four-weeks with added Li2CO3 (1 mM). Li was stopped followed by a
continuous 4-week period of AZT. Mice were evaluated on a weekly basis
for their hematological toxicity by measurement of peripheral blood
indices and progenitor cells from marrow and spleen for the eight-week
study period. RESULTS: AZT induced dose-dependent toxicity that was
measured by reduced indices and progenitor cells from marrow and spleen;
however, in the AZT groups receiving Li, toxicity was reduced
significantly (P value < 0.05) not only during the course of combined
AZT and Li, but more importantly, the ability of Li to influence AZT
toxicity carried over in the groups that had previously received Li and
now had received only AZT compared to AZT controls.
DISCUSSION/CONCLUSIONS: Use of Li provides an effective treatment to
minimize AZT toxicity with lasting effects.
DE Animal Bone Marrow/DRUG EFFECTS/PATHOLOGY Dose-Response Relationship,
Drug Drug Administration Schedule Hematopoietic Stem
Cells/CYTOLOGY/DRUG EFFECTS/PATHOLOGY Lithium Carbonate/*PHARMACOLOGY
Mice Mice, Inbred C57BL Mitotic Index/DRUG EFFECTS Spleen/DRUG
EFFECTS/PATHOLOGY Zidovudine/*TOXICITY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).